Combination of sedating and non sedating antihistamines
No dose adaptation is necessary for elderly or renally (kidney) impaired patients. S., it is classified as category B in pregnancy, meaning animal reproduction studies have failed to demonstrate a risk to the fetus but no adequate and well-controlled studies in pregnant women have been conducted.
This page covers: Types of antihistamines How to take them Side effects Taking them with other medicines, food or alcohol Who can take them – including pregnancy advice How they work There are many types of antihistamine.
Substances that act as inhibitors of the CYP3A4 enzyme such as ketoconazole, erythromycin, cimetidine, and furanocoumarin derivatives (found in grapefruit) lead to increased plasma levels of loratadine.
This had clinically significant effects in controlled trials of higher-than-usual doses of loratadine (20 mg).
Also available are quick-dissolving tablets, which are marketed as being faster to get into one's circulatory system, but require special handling to avoid degrading in the package.
Patients with severe hepatic (liver) disorders may need to start with a lower dose.